NFKB1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1MDI, 1MDJ, 1MDK, 1NFI, 1SVC, 2DBF, 2O61, 3GUT

Identifiers

Aliases

NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, CVID12, nuclear factor kappa B subunit 1

External IDs

OMIM: 164011 MGI: 97312 HomoloGene: 2971 GeneCards: NFKB1

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • RNA polymerase II distal enhancer sequence-specific DNA binding • protein homodimerization activity • chromatin binding • protein binding • DNA binding • sequence-specific DNA binding • actinin binding • regulatory region DNA binding • identical protein binding • transcription regulatory region sequence-specific DNA binding • protein heterodimerization activity
Cellular component	• cytoplasm • mitochondrion • nucleus • I-kappaB/NF-kappaB complex • nucleoplasm • extracellular region • cytosol • secretory granule lumen • specific granule lumen
Biological process	• negative regulation of cellular protein metabolic process • cellular response to interleukin-6 • positive regulation of canonical Wnt signaling pathway • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of vitamin D biosynthetic process • Fc-epsilon receptor signaling pathway • negative regulation of interleukin-12 biosynthetic process • cellular response to mechanical stimulus • NIK/NF-kappaB signaling • stress-activated MAPK cascade • negative regulation of inflammatory response • apoptotic process • response to muscle stretch • regulation of transcription, DNA-templated • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • negative regulation of calcidiol 1-monooxygenase activity • positive regulation of hyaluronan biosynthetic process • membrane protein intracellular domain proteolysis • inflammatory response • I-kappaB kinase/NF-kappaB signaling • positive regulation of miRNA metabolic process • cellular response to nicotine • negative regulation of transcription from RNA polymerase II promoter • positive regulation of macrophage derived foam cell differentiation • positive regulation of NF-kappaB transcription factor activity • negative regulation of cholesterol transport • negative regulation of transcription, DNA-templated • negative regulation of cytokine production • positive regulation of lipid storage • cellular response to dsRNA • cellular response to peptide hormone stimulus • T cell receptor signaling pathway • positive regulation of type I interferon production • positive regulation of transcription from RNA polymerase II promoter • signal transduction • cellular response to lipopolysaccharide • cellular response to interleukin-1 • innate immune response • negative regulation of apoptotic process • negative regulation of gene expression • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4790


18033

Ensembl


ENSG00000109320


ENSMUSG00000028163

UniProt


P19838


P25799

RefSeq (mRNA)


NM_001165412 NM_003998 NM_001319226


NM_008689

RefSeq (protein)


NP_001158884 NP_001306155 NP_003989 NP_001158884.1 NP_001306155.1


NP_032715

Location (UCSC)

Chr 4: 102.5 – 102.62 Mb

Chr 3: 135.58 – 135.69 Mb

PubMed search

1MDI, 1MDJ, 1MDK, 1NFI, 1SVC, 2DBF, 2O61, 3GUT

NM_001165412
NM_003998
NM_001319226

NM_008689

NP_001158884
NP_001306155
NP_003989
NP_001158884.1
NP_001306155.1

...
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