NFATC4

NFATC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YRP
Identifiers
Aliases	NFATC4, NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4
External IDs	MGI: 1920431 HomoloGene: 3349 GeneCards: NFATC4
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • peroxisome proliferator activated receptor binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • transcription factor complex • nucleus • cytoplasm • cytosol • nuclear speck Biological process • cell differentiation • regulation of transcription, DNA-templated • cellular response to lithium ion • negative regulation of chromatin binding • cellular response to UV • negative regulation of Wnt signaling pathway • calcineurin-NFAT signaling cascade • positive regulation of apoptotic signaling pathway • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of protein binding • smooth muscle cell differentiation • transcription, DNA-templated • regulation of synaptic plasticity • negative regulation of synapse maturation • heart development • negative regulation of dendrite morphogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of tumor necrosis factor production • branching involved in blood vessel morphogenesis • cellular respiration • positive regulation of apoptotic process • inflammatory response • muscle cell development • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • cellular response to ionomycin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4776	73181
Ensembl	ENSG00000100968	ENSMUSG00000023411
UniProt	Q14934	Q8K120
RefSeq (mRNA)	NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_004554 NM_001320043	NM_001168346 NM_023699
RefSeq (protein)	NP_001129494 NP_001185894 NP_001185895 NP_001185896 NP_001275731 NP_001306972 NP_004545	NP_001161818.1 NP_076188.3 NP_001161818 NP_076188
Location (UCSC)	Chr 14: 24.37 – 24.38 Mb	Chr 14: 55.82 – 55.83 Mb
PubMed search

2YRP

4776

73181

ENSG00000100968

ENSMUSG00000023411

Q14934

Q8K120

NM_004554
NM_001320043

NM_001168346
NM_023699

NP_001306972
NP_004545

NP_001161818.1
NP_076188.3
NP_001161818
NP_076188

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.

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