NFATC3

NFATC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XRW, 2XS0
Identifiers
Aliases	NFATC3, NFAT4, NFATX, nuclear factor of activated T-cells 3
External IDs	MGI: 103296 HomoloGene: 27827 GeneCards: NFATC3
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Cellular component • cytoplasm • nucleoplasm • nucleus • cytosol Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • Fc-epsilon receptor signaling pathway • inflammatory response • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4775	18021
Ensembl	ENSG00000072736	ENSMUSG00000031902
UniProt	Q12968	P97305
RefSeq (mRNA)	NM_173165 NM_004555 NM_173163 NM_173164	NM_010901
RefSeq (protein)	NP_004546 NP_775186 NP_775188 NP_004546.1 NP_775188.1	n/a
Location (UCSC)	Chr 16: 68.08 – 68.23 Mb	Chr 8: 106.06 – 106.13 Mb
PubMed search

2XRW, 2XS0

4775

18021

ENSG00000072736

ENSMUSG00000031902

Q12968

P97305

NM_173165
NM_004555
NM_173163
NM_173164

NM_010901

NP_004546
NP_775186
NP_775188
NP_004546.1
NP_775188.1

n/a

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.

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Wikipedia