NFAT5

NFAT5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IMH
Identifiers
Aliases	NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP, nuclear factor of activated T-cells 5, tonicity-responsive, nuclear factor of activated T-cells 5
External IDs	MGI: 1859333 HomoloGene: 4811 GeneCards: NFAT5
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • response to osmotic stress • regulation of calcineurin-NFAT signaling cascade • cytokine production • positive regulation of gene expression • excretion • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • GO:0006350 transcription, DNA-templated • signal transduction • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10725	54446
Ensembl	ENSG00000102908	ENSMUSG00000003847
UniProt	O94916	Q9WV30
RefSeq (mRNA)	NM_001113178 NM_006599 NM_138713 NM_138714 NM_173214 NM_173215	NM_001286260 NM_018823 NM_133957
RefSeq (protein)	NP_001106649 NP_006590 NP_619727 NP_619728 NP_775321 NP_775322	NP_001273189.1 NP_061293.2 NP_598718.2 NP_001273189 NP_061293 NP_598718
Location (UCSC)	Chr 16: 69.57 – 69.7 Mb	Chr 8: 107.29 – 107.38 Mb
PubMed search

1IMH

10725

54446

ENSG00000102908

ENSMUSG00000003847

O94916

Q9WV30

NM_173215

NM_001286260
NM_018823
NM_133957

NP_775322

NP_598718

Nuclear factor of activated T-cells 5, also known as NFAT5, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress.

The product of this gene is a member of the nuclear factors of activated T cells (NFAT) family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.

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Wikipedia