NEU3

NEU3
Identifiers
Aliases	NEU3, SIAL3, neuraminidase 3 (membrane sialidase), neuraminidase 3, membrane sialidase, neuraminidase 3
External IDs	MGI: 1355305 HomoloGene: 4847 GeneCards: NEU3
Gene ontology Molecular function • alpha-sialidase activity • exo-alpha-(2->6)-sialidase activity • exo-alpha-(2->8)-sialidase activity • hydrolase activity, acting on glycosyl bonds • exo-alpha-(2->3)-sialidase activity • hydrolase activity • exo-alpha-sialidase activity Cellular component • cytoplasm • intracellular membrane-bounded organelle • membrane • plasma membrane • integral component of plasma membrane Biological process • glycosphingolipid metabolic process • carbohydrate metabolic process • lipid metabolic process • lipid catabolic process • oligosaccharide catabolic process • metabolic process • ganglioside catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10825	50877
Ensembl	ENSG00000162139	ENSMUSG00000035239
UniProt	Q9UQ49	Q9JMH7
RefSeq (mRNA)	NM_006656	NM_016720
RefSeq (protein)	NP_006647	NP_057929
Location (UCSC)	Chr 11: 74.99 – 75.02 Mb	Chr 7: 99.81 – 99.83 Mb
PubMed search

10825

50877

ENSG00000162139

ENSMUSG00000035239

Q9UQ49

Q9JMH7

NM_006656

NM_016720

NP_006647

NP_057929

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.

NEU3 has been shown to interact with Grb2.

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Wikipedia