NEU1

NEU1
Identifiers
Aliases	NEU1, NANH, NEU, SIAL1, neuraminidase 1 (lysosomal sialidase), neuraminidase 1
External IDs	MGI: 97305 HomoloGene: 375 GeneCards: NEU1
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,857,659 bp End 31,862,906 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.48 cM Start 34,931,253 bp End 34,935,953 bp
Gene ontology Molecular function • exo-alpha-(2->3)-sialidase activity • exo-alpha-(2->8)-sialidase activity • exo-alpha-(2->6)-sialidase activity • hydrolase activity • hydrolase activity, acting on glycosyl bonds • exo-alpha-sialidase activity • protein binding • alpha-sialidase activity Cellular component • cytoplasmic vesicle • intracellular membrane-bounded organelle • lysosomal membrane • extracellular exosome • lysosome • plasma membrane • lysosomal lumen • cell junction • membrane • extracellular region • specific granule lumen Biological process • ganglioside catabolic process • lipid catabolic process • lipid metabolic process • metabolism • oligosaccharide catabolic process • glycosphingolipid metabolic process • neutrophil degranulation • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4758	18010
Ensembl	ENSG00000227129 ENSG00000184494 ENSG00000223957 ENSG00000234846 ENSG00000204386 ENSG00000234343 ENSG00000227315 ENSG00000228691	ENSMUSG00000007038
UniProt	Q99519	O35657
RefSeq (mRNA)	NM_000434	NM_010893
RefSeq (protein)	NP_000425	NP_035023
Location (UCSC)	Chr 6: 31.86 – 31.86 Mb	Chr 6: 34.93 – 34.94 Mb
PubMed search

4758

18010

ENSG00000234343
ENSG00000227315
ENSG00000228691

ENSMUSG00000007038

Q99519

O35657

NM_000434

NM_010893

NP_000425

NP_035023

Sialidase 1 (lysosomal sialidase), also known as NEU1 is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.

The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.

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