NDN (gene)

NDN
Identifiers
Aliases	NDN, HsT16328, PWCR, necdin, MAGE family member
External IDs	MGI: 97290 HomoloGene: 20559 GeneCards: NDN
Gene ontology Molecular function • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • gamma-tubulin binding Cellular component • cytoplasm • perikaryon • centrosome • cell projection • nucleus • nucleoplasm • cytosol Biological process • respiratory system process • genetic imprinting • neurotrophin TRK receptor signaling pathway • regulation of transcription, DNA-templated • axonogenesis • neuron development • neuron migration • multicellular organismal homeostasis • transcription from RNA polymerase II promoter • post-embryonic development • transcription, DNA-templated • nervous system development • respiratory gaseous exchange • central nervous system development • axon extension • sensory perception of pain • regulation of growth • axonal fasciculation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • glial cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4692	17984
Ensembl	ENSG00000182636	ENSMUSG00000033585
UniProt	Q99608	P25233
RefSeq (mRNA)	NM_002487	NM_010882
RefSeq (protein)	NP_002478	NP_035012.2 NP_035012
Location (UCSC)	Chr 15: 23.69 – 23.69 Mb	Chr 7: 62.35 – 62.35 Mb
PubMed search

4692

17984

ENSG00000182636

ENSMUSG00000033585

Q99608

P25233

NM_002487

NM_010882

NP_002478

NP_035012.2
NP_035012

Necdin is a protein that in humans is encoded by the NDN gene.

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.

Necdin is used to stimulate growth regulation,and DNA-dependent transcription regulation.

NDN (gene) has been shown to interact with:

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Wikipedia