NAPSA

NAPSA
Identifiers
Aliases	NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin A aspartic peptidase
External IDs	MGI: 109365 HomoloGene: 68418 GeneCards: NAPSA
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 50,358,477 bp End 50,365,830 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 44,572,380 bp End 44,586,862 bp
Gene ontology Molecular function • endopeptidase activity • hydrolase activity • aspartic-type endopeptidase activity • peptidase activity Cellular component • extracellular region • lysosome • extracellular exosome • alveolar lamellar body • multivesicular body lumen • extracellular space Biological process • surfactant homeostasis • cellular protein metabolic process • protein catabolic process • proteolysis • membrane protein proteolysis • autophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9476	16541
Ensembl	ENSG00000131400	ENSMUSG00000002204
UniProt	O96009	O09043
RefSeq (mRNA)	NM_004851	NM_008437
RefSeq (protein)	NP_004842	NP_032463
Location (UCSC)	Chr 19: 50.36 – 50.37 Mb	Chr 19: 44.57 – 44.59 Mb
PubMed search

9476

16541

ENSG00000131400

ENSMUSG00000002204

O96009

O09043

NM_004851

NM_008437

NP_004842

NP_032463

Napsin-A is a protein that is encoded in humans by the NAPSA gene.

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.

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Wikipedia