NAAG peptidase

FOLH1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4P4J, 1Z8L, 2C6C, 2C6G, 2C6P, 2CIJ, 2JBJ, 2JBK, 2OOT, 2OR4, 2PVV, 2PVW, 2XEF, 2XEG, 2XEI, 2XEJ, 3BHX, 3BI0, 3BI1, 3BXM, 3D7D, 3D7F, 3D7G, 3D7H, 3IWW, 3RBU, 3SJE, 3SJF, 3SJG, 3SJX, 4JYW, 4JZ0, 4LQG, 4MCP, 4MCQ, 4MCR, 4MCS, 4NGM, 4NGN, 4NGP, 4NGQ, 4NGR, 4NGS, 4NGT, 4OC0, 4OC1, 4OC2, 4OC3, 4OC4, 4OC5, 4OME, 4P44, 4P45, 4P4B, 4P4D, 4P4E, 4P4F, 4P4I, 4W9Y, 4X3R, 5F09, 5D29, 5ELY
Identifiers
Aliases	FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, folate hydrolase (prostate-specific membrane antigen) 1, folate hydrolase 1
External IDs	OMIM: 600934 HomoloGene: 136782 GeneCards: FOLH1
Gene ontology Molecular function • metal ion binding • tetrahydrofolyl-poly(glutamate) polymer binding • peptidase activity • catalytic activity • metallocarboxypeptidase activity • carboxypeptidase activity • Ac-Asp-Glu binding • hydrolase activity • metallopeptidase activity • dipeptidase activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • extracellular exosome Biological process • cellular amino acid biosynthetic process • proteolysis • C-terminal protein deglutamylation • metabolism • folic acid-containing compound metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2346	n/a
Ensembl	ENSG00000086205	n/a
UniProt	Q04609	n/a
RefSeq (mRNA)	NM_001014986 NM_001193471 NM_001193472 NM_001193473 NM_004476 NM_001351236	n/a
RefSeq (protein)	NP_001014986 NP_001180400 NP_001180401 NP_001180402 NP_004467 NP_001338165	n/a
Location (UCSC)	Chr 11: 49.15 – 49.21 Mb	n/a
PubMed search		n/a

glutamate carboxypeptidase II
Reaction Scheme of NAAG Degradation by GCPII: GCPII + NAAG → GCPII-NAAG complex → Glutamate + NAA
Identifiers
EC number	3.4.17.21
CAS number	111070-04-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

4P4J, 1Z8L, 2C6C, 2C6G, 2C6P, 2CIJ, 2JBJ, 2JBK, 2OOT, 2OR4, 2PVV, 2PVW, 2XEF, 2XEG, 2XEI, 2XEJ, 3BHX, 3BI0, 3BI1, 3BXM, 3D7D, 3D7F, 3D7G, 3D7H, 3IWW, 3RBU, 3SJE, 3SJF, 3SJG, 3SJX, 4JYW, 4JZ0, 4LQG, 4MCP, 4MCQ, 4MCR, 4MCS, 4NGM, 4NGN, 4NGP, 4NGQ, 4NGR, 4NGS, 4NGT, 4OC0, 4OC1, 4OC2, 4OC3, 4OC4, 4OC5, 4OME, 4P44, 4P45, 4P4B, 4P4D, 4P4E, 4P4F, 4P4I, 4W9Y, 4X3R, 5F09, 5D29, 5ELY