Myocardial perfusion imaging

Myocardial perfusion imaging
Myocardial perfusion scan with thallium-201 for the rest images (bottom rows) and Tc-Sestamibi for the stress images (top rows)
ICD-10-PCS	C22G
MeSH	D055414
OPS-301 code	3-704, 3-721
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Myocardial perfusion scan (also referred to as MPI) is a nuclear medicine procedure that illustrates the function of the heart muscle (myocardium).

It evaluates many heart conditions, such as coronary artery disease (CAD),hypertrophic cardiomyopathy and heart wall motion abnormalities. The function of the myocardium is also evaluated by calculating the left ventricular ejection fraction (LVEF) of the heart. This scan is done in conjunction with a cardiac stress test.

Planar techniques, such as conventional scintigraphy, are rarely used. Rather, Single-photon emission computed tomography (SPECT) is more common in the US. With multihead SPECT systems, imaging can often be completed in less than 10 minutes. With SPECT, interior and posterior abnormalities and small areas of infarction can be identified, as well as the occluded blood vessels and the mass of infarcted and viable myocardium.The usual isotopes for such studies are either Thallium-201 or Technetium-99m.

Experimental and epidemiologic evidence has linked exposure to low-dose ionizing radiation with up to 2% of solid cancers and leukemia. Workers are monitored and limited to 50 mSv annually in the United States, but medical patients are not typically monitored.

From 1993-2001, myocardial perfusion scans in the US increased >6%/y with "no justification", according to a commentary by Lauer. Mycardial perfusion imaging scans are "powerful predictors of future clinical events", and in theory may identify patients for whom aggressive therapies should improve outcome. But this is "only a hypothesis, not a proof", wrote Lauer. There are no randomized controlled trials to demonstrate any benefits, and there is a small but cumulative danger from radiation.