Myelin-associated glycoprotein

MAG
Identifiers
Aliases	MAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
External IDs	OMIM: 159460 MGI: 96912 HomoloGene: 1771 GeneCards: MAG
Gene ontology Molecular function • receptor binding • protein kinase binding • carbohydrate binding • sialic acid binding • protein homodimerization activity • ganglioside GT1b binding • lipid binding Cellular component • cytoplasm • integral component of membrane • membrane • myelin sheath adaxonal region • Schmidt-Lanterman incisure • paranode region of axon • mesaxon • plasma membrane • integral component of plasma membrane • myelin sheath • compact myelin • membrane raft Biological process • negative regulation of neuron differentiation • substantia nigra development • positive regulation of astrocyte differentiation • nervous system development • positive regulation of myelination • cellular response to mechanical stimulus • negative regulation of axonogenesis • leukocyte migration • cell adhesion • negative regulation of neuron projection development • central nervous system myelination • negative regulation of axon extension • negative regulation of neuron apoptotic process • cell-cell adhesion via plasma-membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4099	17136
Ensembl	ENSG00000105695	ENSMUSG00000036634
UniProt	P20916	P20917
RefSeq (mRNA)	NM_080600 NM_001199216 NM_002361	NM_010758
RefSeq (protein)	NP_001186145 NP_002352 NP_542167	NP_034888.1 NP_001333013 NP_001333014 NP_001333015 NP_001333016 NP_001333017 NP_001333018 NP_034888
Location (UCSC)	Chr 19: 35.29 – 35.31 Mb	Chr 7: 30.9 – 30.91 Mb
PubMed search

myelin associated glycoprotein
Identifiers
Symbol	MAG
Alt. symbols	GMA
Entrez	4099
HUGO	6783
OMIM	159460
RefSeq	NM_080600
UniProt	P20916
Other data
Locus	Chr. 19 q13.1

4099

17136

ENSG00000105695

ENSMUSG00000036634

P20916

P20917

NM_080600
NM_001199216
NM_002361

NM_010758

NP_001186145
NP_002352
NP_542167

NP_001333017
NP_001333018
NP_034888

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during nerve regeneration.

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