Mydriatic

Mydriasis
Pupil dilated for examination by ophthalmologist
Classification and external resources
Specialty	Ophthalmology
ICD-10	H57.0
ICD-9-CM	379.43
OMIM	159420 159410 106240
DiseasesDB	8603
MeSH	D015878
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Mydriasis (/mᵻˈdraɪ.əsɪs/) is the dilation of the pupil, usually defined as when having a non-physiological cause, but sometimes defined as potentially being a physiological pupillary response. Non-physiological causes of mydriasis include disease, trauma, or the use of drugs. Normally, as part of the pupillary light reflex, the pupil dilates in the dark and constricts in the light to respectively improve vividity at night and to protect the retina from sunlight damage during the day. A mydriatic pupil will remain excessively large even in a bright environment. The excitation of the radial fibres of the iris which increases the pupillary aperture is referred to as a mydriasis. More generally, mydriasis also refers to the natural dilation of pupils, for instance in low light conditions or under sympathetic stimulation.

An informal term for mydriasis is blown pupil, and is used by medical providers. It is usually used to refer to a fixed, unilateral mydriasis, which could be a symptom of raised intracranial pressure.

The opposite, constriction of the pupil, is referred to as miosis. Both mydriasis and miosis can be physiological. Anisocoria is the condition of one pupil being more dilated than the other.

There are two types of muscle that control the size of the iris: the iris sphincter, composed of circularly arranged muscle fibers, and the iris dilator, composed of radially arranged muscle fibers. The sphincter is innervated by (signaled by nerves of) the parasympathetic nervous system; the dilator by the sympathetic nervous system. Sympathetic stimulation of the adrenergic receptors causes the contraction of the radial muscle and subsequent dilation of the pupil. Conversely, parasympathetic stimulation causes contraction of the circular muscle and constriction of the pupil.

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