"Mustang Sally" is a rhythm and blues (R&B) song written and first recorded by Mack Rice in 1965. It was released on the Blue Rock label (4014) in May 1965 with "Sir Mack Rice" as the artist. The song uses an AAB layout with a 24-bar structure.

It gained greater popularity when Wilson Pickett covered it the following year on a single, a version that was also released on the 1966 album, The Wicked Pickett. Also in 1966, John Lee Hooker recorded an entirely different song with a similar title — "Mustang Sally & GTO".

According to music historian Tom Shannon the song started as a joke when singer Della Reese wanted a new Ford Mustang. Rice called the early version "Mustang Mama" but changed the title after Aretha Franklin suggested "Mustang Sally".

In the liner notes for The Rascals Anthology, Felix Cavaliere states that The Young Rascals recorded "Mustang Sally" and "Land of a Thousand Dances" before Pickett and that Atlantic Records "copped those two songs from them and gave them to Pickett" to record. When Cavaliere does his flashback concerts, he also recounts how Rice thanked him for having been the B-side of the Young Rascals' hit, "Good Lovin'", explaining that the royalties were paid by records sold — thus, the B-side writer was paid for an equal number of sales as the A-side.

Rice's version made it to #15 on the U.S. R&B charts in 1965. Pickett's version climbed to #6 on the R&B charts and #23 on the Pop charts in 1966, #4 in Canada on the (RPM) charts, and #28 in the UK Singles Chart on its original release and #62, when it was released again in 1987.

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