Multidrug resistance-associated protein 2

ABCC2
Identifiers
Aliases	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP, Multidrug resistance-associated protein 2, ATP binding cassette subfamily C member 2
External IDs	MGI: 1352447 HomoloGene: 68052 GeneCards: ABCC2
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.2 Start 99,782,732 bp End 99,852,192 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 C3|19 36.67 cM Start 43,782,192 bp End 43,840,740 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATPase activity • nucleotide binding • protein binding • ATP binding • transporter activity • protein domain specific binding • ATPase activity, coupled to transmembrane movement of substances • organic anion transmembrane transporter activity • ATPase-coupled anion transmembrane transporter activity • bilirubin transmembrane transporter activity Cellular component • integral component of membrane • membrane • cell surface • plasma membrane • apical plasma membrane • brush border membrane • intercellular canaliculus • integral component of plasma membrane Biological process • response to steroid hormone • response to arsenic-containing substance • response to drug • prostaglandin transport • response to methotrexate • thyroid hormone transport • drug transmembrane transport • transmembrane transport • cellular chloride ion homeostasis • response to oxidative stress • response to estrogen • response to heat • bilirubin transport • female pregnancy • mercury ion transport • canalicular bile acid transport • antibiotic metabolic process • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to interleukin-6 • cellular response to tumor necrosis factor • cellular response to dexamethasone stimulus • response to antineoplastic agent • ATP hydrolysis coupled anion transmembrane transport • benzylpenicillin metabolic process • cellular response to hormone stimulus • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1244	12780
Ensembl	ENSG00000023839	ENSMUSG00000025194
UniProt	Q92887	Q8VI47
RefSeq (mRNA)	NM_000392	NM_013806
RefSeq (protein)	NP_000383	NP_038834
Location (UCSC)	Chr 10: 99.78 – 99.85 Mb	Chr 10: 43.78 – 43.84 Mb
PubMed search

1244

12780

ENSG00000023839

ENSMUSG00000025194

Q92887

Q8VI47

NM_000392

NM_013806

NP_000383

NP_038834

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

MRP2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). More specifically, this protein is a member of the MRP subfamily, which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells.

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