The Muddy River, formerly known as the Moapa River, is a short river located in Clark County, in southern Nevada, United States. It is in the Mojave Desert, approximately 60 miles (97 km) north of Las Vegas.
The Muddy River is approximately 32 miles (51 km) long. It begins as a series of thermal springs in the Moapa Valley before continuing on its course to Lake Mead, where it drains into the northern arm of the lake near Overton, Nevada. Before the Hoover Dam's construction, the Muddy River flowed into the Virgin River.
Near the town of Glendale the Muddy River collects the flow from the Meadow Valley Wash, forming the principal drainage system for southeastern Nevada.
The Moapa Valley area is home to a wide variety of rare and endangered species, including fish, invertebrates, birds, and plants. Three endangered fish inhabit the area: the Moapa dace (Moapa coriacea), the Virgin River chub (Gila seminuda), and the White River springfish (Crenichthys baileyi moapae). These species can be found throughout the various springs, called the Muddy Springs, that feed the Muddy River.
The U.S. Fish and Wildlife Service has created the Moapa National Wildlife Refuge at the Warm Springs Natural Area, as part of the Desert National Wildlife Refuge Complex. In another effort to help protect and preserve the fragile habitats in the Muddy Springs area, the Southern Nevada Water Authority (SNWA) and various environmental associations have organized an effort to conserve these species.