Mu'awiya ibn Hisham (fl. 725–737) was an Arab general, the son of the Umayyad Caliph Hisham ibn Abd al-Malik (r. 723–743), who distinguished himself in the Arab–Byzantine Wars. His son, Abd al-Rahman ibn Mu'awiya, was the founder of the Emirate of Córdoba and the Umayyad line of al-Andalus.
Mu'awiya he was son of the Caliph Hisham ibn Abd Al-Malik and Um Al-Hakam bint Yahia ibn Al-Hakam, one his cousins, is known chiefly for his role in the Arab–Byzantine Wars, where he led many invasions against Byzantine Asia Minor. The first campaign he led was in summer 725, which was carried out in conjunction with a naval attack by Maymun ibn Mihran against Cyprus. According to Arab accounts, Mua'wiya's army reached as far as Dorylaion, capturing many prisoners and sacking several forts. Mu'awiya is also recorded to have launched an expedition in 726, possibly in winter, but nothing specific is known of it. In 727, he led another expedition, alongside Abdallah al-Battal. Battal captured and razed Gangra first, and then their combined forces took the fortress of Ateous, and advanced on Nicaea. Despite a 40-day siege, however, they failed to capture it. In 728 he led the southern expedition into Asia Minor, while his brother Sa'id ibn Hisham led the northern; neither appears to have been particularly successful.
Muslim sources attribute to him the capture of the fortress of Charsianon in September/October 730, but Byzantine sources state that this was done by Mu'awiya's uncle, Maslama ibn Abd al-Malik. In the next year, his forces were reportedly unable to penetrate the frontier, while a secondary expedition by al-Battal was heavily defeated. In 732, Mu'awiya's expedition penetrated as far as Akroinon. In 733, he led an expedition into Paphlagonia. He continued to lead expeditions over the next few years, bit although they ranged deep into Asia Minor in search of plunder—one of his raiding parties reportedly reached Sardeis near the Aegean coast—no major town or fortress appears to have been captured. In summer 737 he again led the southern expedition, but died, according to Theophanes the Confessor, by falling from his horse during a hunt.