Mre11

MRE11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T1I
Identifiers
Aliases	MRE11, ATLD, HNGS1, MRE11B, MRE11A, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease
External IDs	MGI: 1100512 HomoloGene: 4083 GeneCards: MRE11
Gene ontology Molecular function • DNA binding • manganese ion binding • ATP-dependent DNA helicase activity • single-stranded DNA endodeoxyribonuclease activity • protein C-terminus binding • protein binding • 3'-5' exonuclease activity • nuclease activity • endonuclease activity • double-stranded DNA binding • endodeoxyribonuclease activity • exonuclease activity • hydrolase activity • cadherin binding Cellular component • site of double-strand break • cytosol • PML body • nuclear chromosome, telomeric region • nucleus • cytoplasm • nucleoplasm • chromosome, telomeric region • chromosome • Mre11 complex Biological process • reciprocal meiotic recombination • DNA recombination • telomere maintenance via telomerase • positive regulation of kinase activity • intra-S DNA damage checkpoint • telomeric 3' overhang formation • negative regulation of apoptotic process • chromosome organization • sister chromatid cohesion • cellular response to DNA damage stimulus • positive regulation of telomere maintenance • DNA duplex unwinding • synapsis • negative regulation of DNA endoreduplication • double-strand break repair • meiotic cell cycle • double-strand break repair via homologous recombination • positive regulation of protein autophosphorylation • cell proliferation • mitotic G2 DNA damage checkpoint • viral process • double-strand break repair via nonhomologous end joining • positive regulation of type I interferon production • regulation of mitotic recombination • DNA repair • nucleic acid phosphodiester bond hydrolysis • DNA double-strand break processing • strand displacement • DNA replication • DNA synthesis involved in DNA repair • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4361	17535
Ensembl	ENSG00000020922	ENSMUSG00000031928
UniProt	P49959	Q61216
RefSeq (mRNA)	NM_005590 NM_005591 NM_001330347	NM_018736 NM_001310728
RefSeq (protein)	NP_001317276 NP_005581 NP_005582	NP_001297657 NP_061206
Location (UCSC)	Chr 11: 94.42 – 94.49 Mb	Chr 9: 14.78 – 14.84 Mb
PubMed search

3T1I

4361

17535

ENSG00000020922

ENSMUSG00000031928

P49959

Q61216

NM_005590
NM_005591
NM_001330347

NM_018736
NM_001310728

NP_001317276
NP_005581
NP_005582

NP_001297657
NP_061206

Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

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