Mosely Creek is a large creek in the Pacific Ranges of the Coast Mountains in British Columbia, Canada, flowing southwest to join the Homathko River in its canyon downstream from Tatlayoko Lake, and a short distance above Murderers Bar at 51°16′00″N 124°54′00″W / 51.26667°N 124.90000°W, which is the site of the opening events of the Chilcotin War of 1864.
Tiedemann Creek, which begins at the Tiedemann Glacier on Mount Waddington, is a tributary of Mosley Creek, flowing east from its source to the confluence at 51°18′38″N 124°50′39″W / 51.31056°N 124.84417°W, just above the confluence with the Homathko.