Mometasone furoate

Mometasone furoate

Clinical data
Trade names	Many
AHFS/Drugs.com	Monograph
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Topical, inhalation
ATC code	D07AC13 (WHO) R01AD09 (WHO), R03BA07 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone
Protein binding	98% to 99%
Metabolism	Hepatic
Biological half-life	5.8 hours
Identifiers
IUPAC name (11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate
Synonyms	(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
CAS Number	105102-22-5 Y83919-23-7
PubChem (CID)	441336
DrugBank	DB00764 N
ChemSpider	390091 Y
UNII	8HR4QJ6DW8 N
ChEBI	CHEBI:47564 Y
ChEMBL	CHEMBL1161 Y
ECHA InfoCard	100.125.600
Chemical and physical data
Formula	C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate
Molar mass	427.361 g/mol (Mometasone) 521.4 g/mol (Furoate)
3D model (Jmol)	Interactive image
SMILES O=C(O[C@]2(C(=O)CCl)[C@H](C)C[C@H]3[C@@H]4CCC\1=C\C(=O)\C=C/[C@]/1(C)[C@@]4(Cl)[C@@H](O)C[C@]23C)c5occc5
InChI InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1 Y Key:WOFMFGQZHJDGCX-ZULDAHANSA-N Y
NY (what is this?)

Mometasone furoate is a glucocorticoid or corticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of the free form mometasone (INN).

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form) for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy.

Mometasone is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis

Nasal mometasone is used in adults (including the elderly) and children over 2 years to diminishing the symptoms such as hay fever (seasonal allergic rhinitis) and other allergies (perennial rhinitis), including nasal congestion, discharge, pruritus, and sneezing and to treat nasal polyps.

Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties.

It reduces inflammation by causing several effects:

In addition to the glucocorticoid properties of mometasone furoate, it is a very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor.