Missouri Route 221
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| Route information | ||||
| Maintained by MoDOT | ||||
| Length: | 16.317 mi (26.260 km) | |||
| Existed: | c. 2010–2012 – present | |||
| Major junctions | ||||
| West end: |
 Route 21 near Pilot Knob
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| East end: |
 US 67 near Farmington
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| Location | ||||
| Counties: | Iron, St. Francois | |||
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Route 221 is a 16.317-mile-long (26.260 km) east—west highway in eastern Missouri. Its western terminus is at Route 21 near Pilot Knob. Its eastern terminus is at U.S. Route 67 (US 67) near Farmington.
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