Mir-145

mir-145
Conserved secondary structure of mir-145
Identifiers
Symbol	mir-145
Rfam	RF00675
miRBase family	MIPF0000079
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
SO	{{{SO}}}

406937

n/a

ENSG00000276365

n/a

n/a

n/a

n/a

n/a

n/a

n/a

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin. Larsson et al. showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.

miR-145 is hypothesised to be a tumor suppressor. miR-145 has been shown to be down-regulated in breast cancer. miR-145 is also involved in colon cancer and acute myeloid leukemia.