Minamitakaki (南高来郡 Minami-Takaki-gun?, English: South Takaki District) was a district located in Nagasaki Prefecture, Japan.
Minamitakaki District is now equivalent to the cities of Shimabara, Unzen, and Minami-Shimabara.
As of 2003, the district had an estimated population of 117,639 and a density of 293.97 persons per km². The total area was 400.18 km².