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The Homewood campus is the main academic and administrative center of the Johns Hopkins University. It is located at 3400 North Charles Street in Baltimore, Maryland. It houses the two major undergraduate schools: the Zanvyl Krieger School of Arts and Sciences and the Whiting School of Engineering.

In his will Johns Hopkins (1795-1873) left his summer home, Clifton, to the university for its new campus along with $7 million with the intention of the funds being split between the university and a hospital, also named for him. One of his provisions was that only interest obtained from his stock in the Baltimore and Ohio Railroad could be used to build facilities for the university. Unfortunately, after Johns Hopkins' death, the B&O Railroad fell into mismanagement; its eventual collapse was hastened by the Financial Panic and Recession of 1893 and the stock became worthless. Therefore, the original campus of the university was established by first President Daniel Coit Gilman in downtown Baltimore along North Howard Street, between West Center, Little Ross, and West Monument Streets on the west side of the Mount Vernon-Belvedere neighborhood, where buildings were already available. However, this location did not permit room for growth and soon the trustees began to look for a place to move. Eventually, Hopkins would relocate to the former Homewood Estate of Charles Carroll, Jr. (son of Charles Carroll of Carrollton, 1737-1832) built 1801-1803, and the later Wyman Villa estate of JHU Board member William Wyman, built in the 1880s. Here JHU created the park-like main campus of Hopkins Homewood, set on 140 acres (0.57 km²) in what today lies between the north Baltimore neighborhoods of Charles Village (begun in the 1870s as Peabody Heights) to the east, the planned suburban-style communities of Guilford (established 1913) and Roland Park (established 1890s) to the north, and to the west, the mill towns of Hampden-Woodberry along the Jones Falls stream valleys and tributary Stony Run through Wyman Park and the Wyman Park Dell.


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