A ten-member IHSAA-Sanctioned Athletic Conference within the South Central Indiana counties of Clark, Harrison, Jackson, Scott, and Washington.
The conference began in 1958, with seven schools leaving the Southeastern Indiana Conference and allying with three schools from Clark County (whose previous conference affiliations are in need of research). The first decade-plus within the league was stable, as the only change was Brownstown becoming Brownstown Central due to consolidation in Jackson County. Meanwhile, the 1970s proved to be a comparatively tumultuous decade. Mitchell joined the Blue Chip Conference in 1970, seeking for conference rivals to the west. They were replaced by Floyd Central, which had been independent since forming three years earlier. Austin, which did not sponsor football, joined the Southern Athletic Conference in 1974 while maintaining MSC membership. This allowed the Eagles to ally themselves with other non-football schools, yet maintain the traditional rivalries from the SEIC. Silver Creek also did not have football, while Scottsburg dropped it in the 1970s, yet they were much larger than most schools that didn't offer the sport. In fact, Scottsburg is still the largest school without a gridiron program, though one may be revived in 2016.
Floyd Central grew much faster than anticipated, and by 1976 had outgrown the other schools, necessitating a move to the Hoosier Hills Conference. This marked the first time membership had dropped below ten schools, though this would only last for two years. North Harrison, a school that had outgrown the small-school Blue River Conference and was within the MSC footprint, joined after starting their football team, bring the league back to 10 schools with seven football-playing members.
Paoli was the next school to make a change, becoming a charter member of the Patoka Lake Conference while maintaining MSC membership. This lasted for six years, as Paoli decided the more geographically compact PLC was better suited to their needs, leaving the Mid-Southern in 1985. There was concern that Austin would also leave, being the other dual-conference member, but Austin would instead leave the SAC in 1987 being by far the largest school in the Southern, as well as being competitively dominant. The conference would stay with a nine school, six football team setup for 16 years, the longest period of stability since the league was founded.