Founded in 1921, Compañía Mexicana de Aviación, S.A. de C.V. (commonly known as Mexicana) was Mexico's oldest airline and one of the oldest continuously single-branded airlines (after KLM, Avianca and QANTAS), and Mexico's biggest and flagship airline before ceasing operations on August 28, 2010. The group's closure was announced by the company's recently installed management team a short time after the group filed for Concurso Mercantil (Mexican law equivalent to US Chapter 11) and US Chapter 15. On April 4, 2014, a judge declared Mexicana bankrupt and ordered to start selling off the company's assets to repay the airline's obligations. The headquarters of the company were in the Mexicana de Aviación Tower in Colonia del Valle, Benito Juárez, Mexico City.

In addition to domestic services, Mexicana operated flights to various international destinations in North America, Central America, the Caribbean, South America and Europe (until August 31). Their primary hub was Mexico City's Benito Juarez International Airport, with secondary hubs at Cancún International Airport, and Guadalajara's Don Miguel Hidalgo y Costilla International Airport.

Mexicana's main competitors were Aeroméxico (although the two companies "codeshared" on several routes), and low-cost carriers such as Volaris and Interjet. Mexicana was North America's oldest airline and the world's fourth oldest airline operating under the same name, after the Netherlands' KLM, Colombia's Avianca and Australia's Qantas.

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