The Methodist Mission was the Methodist Episcopal Church's 19th-century conversion efforts in the Pacific Northwest. Local Indigenous cultures were introduced to western culture and Christianity. Superintendent Jason Lee was the principal leader for almost a decade. It was a political and religious effort. Two years after the mission began, the church's Board of Foreign Missions described its intent to reclaim "these wandering savages, who are in a very degraded state, to the blessings of Christianity and civilized life." Alongside the missions founded in the region were several secular operations opened. These were maintained to allow for material independence from the Hudson's Bay Company (HBC), then the preeminent economic entity in the region among European descendants.
The Methodists were active participants in the Oregon boundary dispute. Members of mission were part of sending three petitions to United States Congress requesting that the United States extend its jurisdiction over the Pacific Northwest south of the Columbia River. The Methodist stations became important centers for local European-American politics as well. Staff took part in establishing the Provisional Government of Oregon, a settler organization based in the Willamette Valley.
Jason Lee's leadership was criticized by members attached to various posts; his failure to provide adequate financial accounting led to his dismissal in 1843 as superintendent. To reduce the financial burdens on the church, many mission stations were abandoned and the commercial activities were sold off in 1844. While the main station in the Willamette Valley remained active in missionary efforts, it no longer held as much prominence in the changing political scene of Oregon. Despite failure in converting the natives west of the Rocky Mountains, the Methodist Mission played a significant role in the westward expansion of the United States of America.
In 1832, four Nez Perce Indians and Salish (also known as Flatheads) traveled to St. Louis, Missouri. They met with General William Clark of the Lewis and Clark Expedition to inquire about the “white man’s God” from the General. Upon meeting, they told Gen. Clark that they had come from the land of the setting sun in order to learn about the Christians’ book and the white man’s God. General Clark gave them religious instruction but did not give them a Bible. The Indians returned west, several dying along the way, unaware of the stream of events that they had set in motion.