Mesothelin

MSLN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F3F
Identifiers
Aliases	MSLN, MPF, SMRP, mesothelin
External IDs	OMIM: 601051 MGI: 1888992 HomoloGene: 4249 GeneCards: MSLN
Gene ontology Molecular function • protein binding Cellular component • cell surface • anchored component of membrane • Golgi apparatus • membrane • extracellular region • extracellular space • plasma membrane Biological process • pancreas development • cell adhesion • cell-matrix adhesion • C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10232	56047
Ensembl	ENSG00000102854	ENSMUSG00000063011
UniProt	Q13421	Q61468
RefSeq (mRNA)	NM_001177355 NM_005823 NM_013404	NM_018857
RefSeq (protein)	NP_001170826 NP_005814 NP_037536	NP_061345.1 NP_061345
Location (UCSC)	Chr 16: 0.76 – 0.77 Mb	Chr 17: 25.75 – 25.75 Mb
PubMed search

4F3F

10232

56047

ENSG00000102854

ENSMUSG00000063011

Q13421

Q61468

NM_001177355
NM_005823
NM_013404

NM_018857

NP_001170826
NP_005814
NP_037536

NP_061345.1
NP_061345

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.

Mesothelin is a 40 kDa protein present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The protein was first identified by its reactivity with monoclonal antibody K1. Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.

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