Merlin (protein)

NF2

Protein NF2 PDB 1h4r.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4ZRJ, 1H4R, 3U8Z, 4ZRI

Identifiers

NF2, ACN, BANF, SCH, neurofibromin 2 (merlin), neurofibromin 2

External IDs

OMIM: 607379 MGI: 97307 HomoloGene: 2180 GeneCards: NF2

Gene ontology
Molecular function	• cytoskeletal protein binding • protein binding • actin binding
Cellular component	• cytoplasm • cell body • cell projection • membrane • filopodium • ruffle • adherens junction • plasma membrane • apical part of cell • ruffle membrane • early endosome • nucleolus • cortical actin cytoskeleton • perinuclear region of cytoplasm • neuron projection • cleavage furrow • cytoskeleton • nucleus • lamellipodium • filopodium membrane • cytosol
Biological process	• negative regulation of JAK-STAT cascade • regulation of gliogenesis • cell-cell junction organization • regulation of protein stability • negative regulation of cell-cell adhesion • negative regulation of protein kinase activity • mesoderm formation • ectoderm development • negative regulation of DNA replication • Schwann cell proliferation • regulation of neural precursor cell proliferation • regulation of protein localization to nucleus • negative regulation of cell-matrix adhesion • odontogenesis of dentin-containing tooth • brain development • negative regulation of cell migration • lens fiber cell differentiation • regulation of cell proliferation • positive regulation of cell differentiation • negative regulation of MAPK cascade • regulation of hippo signaling • hippocampus development • regulation of stem cell proliferation • regulation of neurogenesis • actin cytoskeleton organization • positive regulation of stress fiber assembly • negative regulation of cell proliferation • negative regulation of tyrosine phosphorylation of STAT protein • regulation of apoptotic process • regulation of cell cycle
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE NF2 204991 s at fs.png

PBB GE NF2 210767 at fs.png

PBB GE NF2 211017 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


4771


18016


ENSG00000186575


ENSMUSG00000009073


P35240


P46662

RefSeq (mRNA)

NM_181835 NM_000268 NM_016418 NM_181825 NM_181826
NM_181827 NM_181828 NM_181829 NM_181830 NM_181831 NM_181832 NM_181833 NM_181834


NM_001252250 NM_001252251 NM_001252252 NM_001252253 NM_010898

RefSeq (protein)

NP_000259 NP_057502 NP_861546 NP_861966 NP_861967
NP_861968 NP_861969 NP_861970 NP_861971

NP_001239179.1 NP_001239180.1 NP_001239181.1 NP_001239182.1 NP_035028.2
NP_001239179 NP_001239180 NP_001239181 NP_001239182 NP_035028

Location (UCSC)

Chr 22: 29.6 – 29.7 Mb

Chr 11: 4.77 – 4.85 Mb

PubMed search

4ZRJ, 1H4R, 3U8Z, 4ZRI

ENSG00000186575

ENSMUSG00000009073

NM_181827
NM_181828
NM_181829
NM_181830
NM_181831
NM_181832
NM_181833
NM_181834

NM_001252250
NM_001252251
NM_001252252
NM_001252253
NM_010898

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Wikipedia

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