Melanocortin 5 receptor

MC5R
Identifiers
Aliases	MC5R, MC2, Melanocortin 5 receptor
External IDs	MGI: 99420 HomoloGene: 4321 GeneCards: MC5R
Targeted by Drug
afamelanotide, MT-II
Gene ontology Molecular function • melanocortin receptor activity • hormone binding • protein binding • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4161	17203
Ensembl	ENSG00000176136	ENSMUSG00000007480
UniProt	P33032	P41149
RefSeq (mRNA)	NM_005913	NM_013596
RefSeq (protein)	NP_005904	n/a
Location (UCSC)	Chr 18: 13.82 – 13.83 Mb	Chr 18: 68.34 – 68.34 Mb
PubMed search

4161

17203

ENSG00000176136

ENSMUSG00000007480

P33032

P41149

NM_005913

NM_013596

NP_005904

n/a

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene. It is located on the chromosome 18 in the human genome. When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.

MC5R is necessary for normal sebum production. Stimulation of MC5R promotes fatty acid oxidation in skeletal muscle and lypolysis in adipocytes. MC5R is essential for erythrocyte differentiation. MC5R is involved in inflammation. MC5R helps maintain thermal homeostasis.

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Wikipedia