Melanocortin 4 receptor

MC4R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IQP, 2IQR, 2IQS, 2IQU, 2IQV, 2IQW
Identifiers
Aliases	MC4R, Melanocortin 4 receptor
External IDs	MGI: 99457 HomoloGene: 4320 GeneCards: MC4R
Targeted by Drug
afamelanotide, MT-II, THIQ
Gene ontology Molecular function • G-protein coupled receptor activity • neuropeptide binding • signal transducer activity • peptide hormone binding • melanocyte-stimulating hormone receptor activity • protein binding • melanocortin receptor activity • ubiquitin protein ligase binding Cellular component • integral component of membrane • membrane • plasma membrane • nucleus Biological process • positive regulation of cAMP biosynthetic process • regulation of grooming behavior • G-protein coupled receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • insulin secretion • regulation of feeding behavior • positive regulation of bone resorption • diet induced thermogenesis • response to insulin • feeding behavior • negative regulation of feeding behavior • energy reserve metabolic process • regulation of metabolic process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4160	17202
Ensembl	ENSG00000166603	ENSMUSG00000047259
UniProt	P32245	P56450
RefSeq (mRNA)	NM_005912	NM_016977
RefSeq (protein)	NP_005903	NP_058673.2
Location (UCSC)	Chr 18: 60.37 – 60.37 Mb	Chr 18: 66.86 – 66.86 Mb
PubMed search

2IQP, 2IQR, 2IQS, 2IQU, 2IQV, 2IQW

4160

17202

ENSG00000166603

ENSMUSG00000047259

P32245

P56450

NM_005912

NM_016977

NP_005903

NP_058673.2

Melanocortin 4 receptor is a protein that in humans is encoded by the MC4R gene. It encodes the MC₄ protein, a G protein-coupled receptor that binds α-melanocyte stimulating hormone (α-MSH). In murine models MC₄ receptors have been found to be involved in feeding behaviour, the regulation of metabolism, sexual behaviour, and male erectile function.

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