Melanocortin 3 receptor

MC3R
Identifiers
Aliases	MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL, Melanocortin 3 receptor
External IDs	MGI: 96929 HomoloGene: 7412 GeneCards: MC3R
Targeted by Drug
afamelanotide, Gamma-Melanocyte-stimulating hormone, MT-II
Gene ontology Molecular function • G-protein coupled receptor activity • neuropeptide binding • signal transducer activity • peptide hormone binding • melanocyte-stimulating hormone receptor activity • protein binding • melanocortin receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • homoiothermy • rhythmic process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • regulation of feeding behavior • circadian regulation of gene expression • regulation of heart rate • regulation of blood pressure • phospholipase C-activating G-protein coupled receptor signaling pathway • sodium ion homeostasis • signal transduction • locomotor rhythm Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4159	17201
Ensembl	ENSG00000124089	ENSMUSG00000038537
UniProt	P41968	P33033
RefSeq (mRNA)	NM_019888	NM_008561
RefSeq (protein)	NP_063941	NP_032587.1 NP_032587
Location (UCSC)	Chr 20: 56.25 – 56.25 Mb	Chr 2: 172.25 – 172.25 Mb
PubMed search

4159

17201

ENSG00000124089

ENSMUSG00000038537

P41968

P33033

NM_019888

NM_008561

NP_063941

NP_032587.1
NP_032587

Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.

This gene encodes MC₃, a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis.

Studies performed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), found that two specific polymorphisms in the MC3R gene may be associated with pediatric obesity and greater body mass because of greater energy intake. Children who were homozygous for C17A + G241A consumed approximately 38% more than those who did not contain aforementioned polymorphisms. The study concluded that these genetic variants did not affect energy expenditure.

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