Melanocortin 1 receptor

MC1R
Identifiers
Aliases	MC1R, CMM5, MSH-R, SHEP2, Melanocortin 1 receptor
External IDs	MGI: 99456 HomoloGene: 1789 GeneCards: MC1R
Gene ontology Molecular function • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • signal transducer activity • melanocyte-stimulating hormone receptor activity • protein binding • melanocortin receptor activity • ubiquitin protein ligase binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intracellular Biological process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • multicellular organism development • UV protection • negative regulation of tumor necrosis factor production • UV-damage excision repair • signal transduction • positive regulation of protein kinase A signaling • sensory perception of pain • intracellular signal transduction • melanin biosynthetic process • pigmentation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of protein kinase B signaling • positive regulation of protein kinase C signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4157	17199
Ensembl	ENSG00000258839	ENSMUSG00000074037
UniProt	Q01726	Q01727
RefSeq (mRNA)	NM_002386	NM_008559
RefSeq (protein)	NP_002377	NP_032585.2 NP_032585
Location (UCSC)	Chr 16: 89.91 – 89.92 Mb	Chr 8: 123.41 – 123.41 Mb
PubMed search

4157

17199

ENSG00000258839

ENSMUSG00000074037

Q01726

Q01727

NM_002386

NM_008559

NP_002377

NP_032585.2
NP_032585

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH).

MC1R is one of the key proteins involved in regulating mammalian skin and hair color. It is located on the plasma membrane of specialized cells known as melanocytes, which produce the pigment melanin through the process of melanogenesis. It works by controlling the type of melanin being produced, and its activation causes the melanocyte to switch from generating the yellow or red phaeomelanin by default to the brown or black eumelanin in replacement.

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Wikipedia