Mebeverine

Mebeverine

Clinical data
Trade names	Colofac, Duspamen, Duspatalin and others
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	A03AA04 (WHO)
Legal status
Legal status	UK: P (Pharmacy medicines) US: Not approved In general: ℞ (Prescription only)
Identifiers
IUPAC name (RS)-4-(Ethyl[1-(4-methoxyphenyl)propan-2-yl]amino)butyl 3,4-dimethoxybenzoate
CAS Number	2753-45-9 Y
PubChem CID	4031
ChemSpider	3891 Y
UNII	7F80CC3NNV
KEGG	D04868 Y
ChEMBL	CHEMBL282121 Y
ECHA InfoCard	100.018.546
Chemical and physical data
Formula	C25H35NO5
Molar mass	429.6 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
SMILES O=C(OCCCCN(C(C)Cc1ccc(OC)cc1)CC)c2cc(OC)c(OC)cc2
InChI InChI=1S/C25H35NO5/c1-6-26(19(2)17-20-9-12-22(28-3)13-10-20)15-7-8-16-31-25(27)21-11-14-23(29-4)24(18-21)30-5/h9-14,18-19H,6-8,15-17H2,1-5H3 Y Key:VYVKHNNGDFVQGA-UHFFFAOYSA-N Y

Mebeverine is a drug whose major therapeutic role is in the treatment of irritable bowel syndrome (IBS) and the associated abdominal cramping. It works by relaxing the muscles in and around the gut. It is a musculotropic antispasmodic drug without anticholinergic side effects. The drug is also indicated for treatment of gastrointestinal spasm secondary to organic disorder.

Spastic functional disturbances of the colon:

Mebeverine should be taken 20 minutes before meals.

Mebeverine is an antimuscarinic. It is also an inhibitor of calcium-depot replenishment. Musculotropic compounds act directly on the gut muscles at the cellular level to relax them. This relieves painful muscle spasms of the gut, without affecting its normal motility. Mebeverine is used to relieve symptoms of irritable bowel syndrome and related intestinal disorders that are the result of spasms in the intestinal muscles. These include colicky abdominal pain and cramps, diarrhoea alternating with constipation and flatulence (wind).

Side effects may include:

Since 1978, 21 cases of severe adverse reactions to mebeverine were reported in the Netherlands. Most reactions consisted of urticaria or maculopapular rash, sometimes accompanied by fever, polyarthritis, thrombocytopenia or angioedema.

Very rarely, people taking this medicine may develop allergic reactions.

Mebeverine passes into breast milk, but the amount is considered too small to be harmful to a nursing infant.

Mebeverine is unlikely to affect the ability to operate machinery or to drive, yet not completely out of the question.

It was first registered in 1965.

Mebeverine is a generic drug and is available internationally under many brand names.