Mayor of Mega-City One is a fictional office in the Judge Dredd comic strip in 2000 AD. The most significant mayor to appear in the comic was serial killer PJ Maybe, in disguise as Byron Ambrose.
The real political power in Mega-City One is not held by the mayor but by the unelected judges, headed by the Chief Judge. However, the citizens are allowed some very limited degree of self-government in the form of a democratically elected council headed by a mayor, with powers over relatively minor matters and the authority to make representations to Justice Department. The office did not really exist in any meaningful sense between the years 2104 and 2117.
Mayor Amalfi was mayor until he was implicated in receiving stolen body parts from the morgue, which he used as fertiliser in his private garden. Obese and obnoxious to the Judges, he lived a life of luxury. When his crimes were discovered by Judge Dredd, he accidentally fell to his death while resisting arrest. The true circumstances of his death were covered up to prevent a scandal.
Mayor Jim Grubb was mayor from 2093 to 2104. In 2099 Dredd rescued his son from mutants who had kidnapped him. In 2101 Grubb was arrested by Chief Judge Cal and held in custody in a psychiatric ward, to remove a possible focus point of opposition to Cal's tyrannical reign. Later that year, following Cal's demise, he was re-elected, although the election was disrupted by Father Earth's calamitous attack on the city.
After the Apocalypse War of 2104 Grubb went missing and was presumed dead. However he later resurfaced, having fallen victim to a strange disease (eventually called Grubb's Disease), which gradually turned his body into a fungus. His last words were "please don't eat me!" An airport was named after him.
Following the War the ruined city was struggling to get back onto its feet, and no new mayor was chosen for some time. Instead the chief judge deemed it more expedient to assume direct control over all aspects of governing the city. However, in 2106 matters had returned sufficiently to normal for the Justice Department to allow elections to resume. However, the public had such contempt for the mediocre candidates on offer that they voted for a joke candidate, an orangutan called Dave.