Matthew Stanley Meselson (born May 24, 1930) is a geneticist and molecular biologist currently at Harvard University, known for his discovery of messenger RNA as well as semi-conservative DNA replication. After completing his Ph.D under Linus Pauling at the California Institute of Technology, Meselson became a Professor at Harvard University in 1960, where he has remained, today, as Thomas Dudley Cabot Professor of the Natural Sciences.
In the famous Meselson–Stahl experiment of 1958 he and Frank Stahl demonstrated through nitrogen isotope labeling that DNA is replicated semi-conservatively. In addition, Meselson, François Jacob, and Sydney Brenner discovered the existence of messenger RNA in 1961. Meselson has investigated DNA repair in cells and how cells recognize and destroy foreign DNA, and, with Werner Arber, was responsible for the discovery of restriction enzymes.
Since 1963 he has been interested in chemical and biological defense and arms control, has served as a consultant on this subject to various government agencies. Meselson worked with Henry Kissinger under the Nixon Administration to convince President Richard Nixon to renounce biological weapons, suspend chemical weapons production, and support an international treaty prohibiting the acquisition of biological agents for hostile purposes, which in 1972 became known as the Biological Weapons Convention. He is currently a member of the Committee on International Security and Arms Control of the U.S. National Academy of Sciences.