Matsudaira Nobutsuna (松平 信綱?, December 19, 1596 – May 4, 1662) was a Japanese daimyo of the early Edo period, who ruled the Kawagoe Domain. First serving Tokugawa Iemitsu as a page, Nobutsuna was renowned for his sagacity. He was named a rōjū in 1633. Nobutsuna led the shogunal forces to their final victory over the rebellion at Shimabara. His court title was Izu no Kami, which was the origin of his nickname, "Izu the Wise" (知恵伊豆 Chie Izu?).
Nobutsuna was born in 1596, the son of Ōkōchi Hisatsuna, a senior retainer of Tokugawa Ieyasu. He was adopted as the heir of his uncle, Matsudaira Masatsuna, in 1601. After being introduced to Hidetada and Ieyasu, he was appointed as page to Ieyasu's grandson Iemitsu. He was greatly admired by Iemitsu, and renowned within the Tokugawa administration for his sagacity.
In the early years of his service, he was a hatamoto; he later became a daimyo. In 1623, he received the court title of Izu no Kami. He became daimyo in 1633, receiving the Oshi Domain as his fief.