Kawagoe Domain (川越藩 Kawagoe-han?) was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Musashi Province, Honshū. The domain was centered at Kawagoe Castle, located in what is the city of Kawagoe in Saitama Prefecture.
The domain had its beginning in 1590, when Toyotomi Hideyoshi defeated the Late Hōjō clan in the Siege of Odawara. Hideyoshi awarded vast Hōjō holdings to Tokugawa Ieyasu, who enfoeffed Sakai Shigetada as daimyo of Kawagoe with a assessed kokudaka of 10,000 koku. Shigetada was transferred in 1601, and the next daimyo was appointed in 1609.
Afterwards, the domain was reassigned every couple of generations to a large number of fudai daimyo clans, spending the longest time under the control of a branch of the Echizen Matsudaira clan (1767-1867) with a rating of 170,000 koku.
The final daimyō of Kawagoe, Matsudaira Yasutoshi, served as domain governor until 1871, and was awarded the title of shishaku (marquis) under the kazoku peerage system. Kawagoe Domain subsequently became part of Saitama Prefecture.