Matrix gla protein

MGP
Identifiers
Aliases	MGP, MGLAP, NTI, GIG36, matrix Gla protein
External IDs	MGI: 96976 HomoloGene: 693 GeneCards: MGP
Gene ontology Molecular function • calcium ion binding • extracellular matrix structural constituent • protein binding • structural constituent of bone Cellular component • extracellular matrix • proteinaceous extracellular matrix • extracellular region • extracellular exosome Biological process • multicellular organism development • cell differentiation • cartilage development • cartilage condensation • ossification • regulation of bone mineralization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4256	17313
Ensembl	ENSG00000111341	ENSMUSG00000030218
UniProt	P08493	P19788
RefSeq (mRNA)	NM_001190839 NM_000900	NM_008597
RefSeq (protein)	NP_000891 NP_001177768	NP_032623.1 NP_032623
Location (UCSC)	Chr 12: 14.88 – 14.89 Mb	Chr 6: 136.87 – 136.88 Mb
PubMed search

4256

17313

ENSG00000111341

ENSMUSG00000030218

P08493

P19788

NM_001190839
NM_000900

NM_008597

NP_000891
NP_001177768

NP_032623.1
NP_032623

Matrix gla protein (MGP) is member of a family of vitamin-K2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization.

MGP is found in number body tissues in mammals, birds, and fish. Its mRNA is present in bone, cartilage, heart, and kidney.

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Wikipedia