Maryland Route 478

Maryland Route 478
Knoxville Road
Maryland Route 478 highlighted in red
Route information
Maintained by MDSHA
Length:	1.88 mi (3.03 km)
Existed:	1971 – present
Tourist routes:	Chesapeake and Ohio Canal Scenic Byway
Major junctions
West end:	MD 180 in Knoxville
East end:	Florida Avenue in Brunswick
Location
Counties:	Frederick
Highway system
Maryland highway system Interstate US State Scenic Byways ← MD 477 MD 479 →

Maryland Route 478 (MD 478) is a state highway in the U.S. state of Maryland. Known as Knoxville Road, the state highway runs 1.88 miles (3.03 km) from MD 180 in Knoxville east to Florida Avenue in Brunswick. MD 478 was constructed as MD 70 in the late 1920s. In 1950, MD 70 was replaced with an extended MD 464. MD 478 was assigned to Knoxville Road after MD 464 was rerouted to its present terminus in 1968.

MD 478 begins at an intersection with MD 180 (Jefferson Pike) in Knoxville. Westbound MD 180 provides access to westbound US 340 toward Harpers Ferry and Charles Town. MD 478 heads east as a two-lane highway through a forested area parallel to the Potomac River, Chesapeake and Ohio Canal, and CSX's Metropolitan Subdivision. The state highway crosses several streams that flow into the Potomac River. After passing through the community of New Addition, MD 478 enters the town of Brunswick, where the state highway ends at Florida Avenue. The roadway continues east as Potomac Street, the main street of Brunswick that passes through the Brunswick Historic District. Potomac Street leads to Maple Street, which heads south to the historic Brunswick train station on MARC's Brunswick Line.