Marie de Lorraine (12 August 1674 – 30 October 1724) was a princess of the House of Lorraine-Guise and Princess of Monaco as consort of Antonio I of Monaco. She was the mother of Louise Hippolyte Grimaldi, the only sovereign Princess of Monaco.

Marie was the ninth of fourteen children born to Louis de Lorraine, Count d'Armagnac and Catherine de Neufville. Her father was a member of the House of Guise, cadet branch of the House of Lorraine, where he held the rank of a prince étranger at the French court.Mademoiselle d'Armagnac. Her mother was a daughter of Nicolas de Neufville-Villeroy, a marshal of France and the governor of Louis XIV during the latter's youth.

The couple signed their wedding contract on 8 June 1688. In a ceremony conducted by Pierre du Cambout de Coislin in the royal chapel of Versailles, Marie married Antonio Grimaldi, Duke of Valentinois on 13 June 1688. As part of the marriage contract, Louis XIV gave the House of Grimaldi the official rank of Foreign Princes at court.

Her husband was the son and heir of Louis I, Prince of Monaco and Catherine Charlotte de Gramont, a former mistress of Louis XIV who had arranged the marriage between Marie and Antonio. Court gossips later stated that the match had been a scheme of Madame de Maintenon, who feared that if she did not remove Marie from court she would become mistress to the king. However Madame de Maintenon wrote that Marie was one of the most "likeable women in the kingdom".

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