Marco De Gregorio (12 March 1829 – 16 February 1876) was an Italian painter, who would form part of the School of Resina, painting works that spanned the spectrum from historical to genre topics.
He was born in Resina (present day Ercolano) near Naples. He studied at the Academy of Fine Arts of Naples after 1850, where he was influenced by Gonsalvo Carelli and Giacinto Gigante. An ardent patriot, in 1860 he joined Garibaldi and even participated in the Battle of Volturnus. Returning to Campania in 1860-1861, he moved to Resina, where Giuseppe De Nittis, Adriano Cecioni, and Federigo Rossano where also soon working. These would constitute the nucleus of the School of Resina. Circa 1870, he took a trip to Egypt, and some of his subsequent paintings have orientalist themes. He died in Resina.