Manuel Camacho Solís (March 30, 1946 – June 5, 2015) was a Mexican politician who served in the cabinets of presidents Miguel de la Madrid and Carlos Salinas. Born in Mexico City to Manuel Camacho Lopez and Luz Solís, he belonged to the Frente Amplio Progresista.
Camacho Solís joined the Institutional Revolutionary Party (PRI) in 1965, and in 1988 he became that party's general secretary.
Camacho met Carlos Salinas at the National Autonomous University of Mexico (UNAM), where they became close friends. Camacho followed Salinas's trajectory in the Planning Ministry under the administration of Miguel de la Madrid. In 1985 he was elected to the Chamber of Deputies, and in 1986 he was appointed to the cabinet as Minister of Urban Development. When Salinas took over the presidency in 1988, Camacho was appointed Head of Government of the Federal District (until 1997, the Federal District's Heads of Government, Regentes, were directly appointed by the President of the Republic).
On November 13, 1993, Camacho was designated Secretary of Foreign Affairs. Due to the Zapatista uprising, Luis Donaldo Colosio's assassination in March 1994, and Camacho's failed attempt to clinch the party's presidential nomination, Camacho broke with the PRI. The complicated relationship between Camacho, Salinas, Colosio and Ernesto Zedillo (who was selected to replace Colosio as the PRI's presidential candidate) was the source of many rumors surrounding Colosio's assassination.