Mammalian target of rapamycin

MTOR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Identifiers
Aliases	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin
External IDs	OMIM: 601231 MGI: 1928394 HomoloGene: 3637 GeneCards: MTOR
Targeted by Drug
dactolisib, everolimus, ridaforolimus, temsirolimus
Gene ontology Molecular function • RNA polymerase III type 1 promoter DNA binding • protein domain specific binding • TFIIIC-class transcription factor binding • kinase activity • ATP binding • RNA polymerase III type 3 promoter DNA binding • protein serine/threonine kinase activity • transferase activity • ribosome binding • protein binding • protein kinase binding • nucleotide binding • phosphoprotein binding • RNA polymerase III type 2 promoter DNA binding • protein kinase activity • macromolecular complex binding Cellular component • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex • membrane • mitochondrion • TORC1 complex • organelle membrane • macromolecular complex • mitochondrial outer membrane • endoplasmic reticulum • TORC2 complex • lysosome • Golgi apparatus • intracellular membrane-bounded organelle • nucleoplasm • neuronal cell body • PML body • endoplasmic reticulum membrane • Golgi membrane • lysosomal membrane • dendrite • endomembrane system • nucleus Biological process • germ cell development • positive regulation of protein phosphorylation • response to amino acid • positive regulation of lipid biosynthetic process • positive regulation of actin filament polymerization • positive regulation of skeletal muscle hypertrophy • positive regulation of granulosa cell proliferation • regulation of carbohydrate utilization • post-embryonic development • positive regulation of dendritic spine development • positive regulation of translation • positive regulation of eating behavior • cell aging • protein phosphorylation • mRNA stabilization • cell projection organization • regulation of glycogen biosynthetic process • positive regulation of cell growth involved in cardiac muscle cell development • negative regulation of autophagy • positive regulation of neuron maturation • positive regulation of glial cell proliferation • macroautophagy • cellular response to hypoxia • negative regulation of cell size • response to cocaine • positive regulation of protein kinase B signaling • cardiac muscle contraction • maternal process involved in female pregnancy • ruffle organization • regulation of GTPase activity • cardiac muscle cell development • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • regulation of membrane permeability • response to insulin • growth • cell growth • regulation of myelination • regulation of fatty acid beta-oxidation • regulation of osteoclast differentiation • positive regulation of cholangiocyte proliferation • regulation of protein kinase B signaling • spinal cord development • positive regulation of peptidyl-tyrosine phosphorylation • social behavior • protein autophosphorylation • negative regulation of cholangiocyte apoptotic process • regulation of brown fat cell differentiation • regulation of protein kinase activity • negative regulation of protein phosphorylation • positive regulation of oligodendrocyte differentiation • regulation of carbohydrate metabolic process • regulation of actin cytoskeleton organization • voluntary musculoskeletal movement • phosphorylation • response to nutrient • multicellular organism growth • negative regulation of muscle atrophy • wound healing • positive regulation of neurogenesis • response to morphine • positive regulation of sensory perception of pain • protein catabolic process • 'de novo' pyrimidine nucleobase biosynthetic process • cellular response to nutrient levels • energy reserve metabolic process • peptidyl-threonine phosphorylation • positive regulation of transcription from RNA polymerase III promoter • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • visual learning • positive regulation of myotube differentiation • positive regulation of cell death • positive regulation of endothelial cell proliferation • negative regulation of iodide transmembrane transport • cardiac muscle tissue development • positive regulation of nitric oxide biosynthetic process • regulation of response to food • T cell costimulation • response to stress • heart morphogenesis • positive regulation of neuron death • cardiac cell development • negative regulation of protein ubiquitination • brain development • positive regulation of gene expression • negative regulation of NFAT protein import into nucleus • long-term memory • heart valve morphogenesis • peptidyl-serine phosphorylation • cell cycle arrest • positive regulation of neuron projection development • regulation of cellular response to heat • positive regulation of lamellipodium assembly • positive regulation of stress fiber assembly • signal transduction • regulation of protein phosphorylation • negative regulation of macroautophagy • TORC1 signaling • anoikis • TOR signaling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2475	56717
Ensembl	ENSG00000198793	ENSMUSG00000028991
UniProt	P42345	Q9JLN9
RefSeq (mRNA)	NM_004958	NM_020009
RefSeq (protein)	NP_004949	NP_064393.2 NP_064393
Location (UCSC)	Chr 1: 11.11 – 11.26 Mb	Chr 4: 148.45 – 148.56 Mb
PubMed search

4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC

2475

56717

ENSG00000198793

ENSMUSG00000028991

P42345

...
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