Malaise

Malaise
Classification and external resources
ICD-10	R53
ICD-9-CM	780.7
MedlinePlus	003089
eMedicine	topic list
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Malaise (/məˈleɪz/ muh-LAZE) is a feeling of general discomfort, uneasiness or pain, often the first indication of an infection or other disease. The word has existed in the French language since at least the 12th century.

The term is also often used figuratively in other contexts; for example, "economic malaise" refers to an economy that is stagnant or in recession (compare depression). The term is particularly associated with the US 1973–75 recession. A speech made by President Jimmy Carter in 1979 is commonly referred to as the "malaise" speech, although the term was not in the speech.

Malaise is a non-specific symptom and can present in the slightest ailment, such as an emotion (causing fainting, a vasovagal response) or hunger (light hypoglycemia), to the most serious conditions (cancer, stroke, heart attack, internal bleeding, etc.).

Malaise expresses a patient's uneasiness that "something is not right" that may need a medical examination to determine the significance.

Malaise is thought to be caused by the activation of an immune response, and the associated pro-inflammatory cytokines.

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