Maipo Province (Spanish: Provincia de Maipo) is one of six provinces in the Santiago Metropolitan Region of central Chile. Its capital is San Bernardo.

As a province, Maipo is a second-level administrative division of Chile, governed by a provincial governor who is appointed by the president.

The province is composed of four communes (Spanish: comunas), each governed by a municipality consisting of an alcalde and municipal council:

The province spans an area of 1,120.5 km² (433 sq mi), making it the second smallest province in the Santiago Metropolitan Region. According to the 2002 census, Maipo was the third most populous province in the region with a total population of 378,444. At that time, there were 336,198 people living in urban areas, 42,246 living in rural areas, 187,789 men, and 190,655 women.

Maipo Valley is the closest Chilean wine region to Santiago, the capital city of Chile. It extends eastwards from the city to the Andes and westward to the coast, stretching south toward the towns and subzones of Padre Hurtado, Peñaflor, Talagante, Isla de Maipo and Melipilla.

The valley includes over 7,302 acres (2,955 ha) of vineyards, more than half of which are dedicated to producing Cabernet Sauvignon or Cabernet blends. It is a historic wine-producing region and the birthplace of the Chilean wine industry, with vines growing there for the past 150 years.

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