Macrophage migration inhibitory factor

MIF

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

1CA7, 1CGQ, 1GCZ, 1GD0, 1GIF, 1LJT, 1MIF, 1P1G, 2OOH, 2OOW, 2OOZ, 3B9S, 3CE4, 3DJH, 3DJI, 3HOF, 3IJG, 3IJJ, 3JSF, 3JSG, 3JTU, 3L5P, 3L5R, 3L5S, 3L5T, 3L5U, 3L5V, 3SMB, 3SMC, 3U18, 4ETG, 4EUI, 4EVG, 4F2K, 4GRN, 4GRO, 4GRP, 4GRQ, 4GRR, 4GRU, 3WNR, 3WNS, 3WNT, 4K9G, 4OSF, 4OYQ, 4P01, 4P0H, 4WR8, 4WRB, 4PKZ, 4PLU, 4TRF, 4TRU, 4XX7, 4XX8, 5BS9, 5BSC, 5BSI, 5EIZ, 5HVV, 5CG4, 5J7Q, 5BSJ, 5HVT, 4PKK, 5B4O, 5HVS, 5J7P

Identifiers

Aliases

MIF, GIF, GLIF, Mmacrophage migration inhibitory factor (glycosylation-inhibiting factor)

External IDs

OMIM: 153620 MGI: 96982 HomoloGene: 55655 GeneCards: MIF

EC number

5.3.3.12

Gene ontology
Molecular function	• cytokine activity • isomerase activity • protein binding • chemoattractant activity • phenylpyruvate tautomerase activity • receptor binding • dopachrome isomerase activity • cytokine receptor binding
Cellular component	• vesicle • myelin sheath • nucleoplasm • extracellular region • cell surface • extracellular exosome • extracellular space • cytoplasm • cytosol • secretory granule lumen • ficolin-1-rich granule lumen
Biological process	• positive regulation of protein phosphorylation • negative regulation of cellular protein metabolic process • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of MAP kinase activity • carboxylic acid metabolic process • positive regulation of chemokine (C-X-C motif) ligand 2 production • immune system process • positive regulation of fibroblast proliferation • negative regulation of cell aging • positive regulation of cytokine secretion • DNA damage response, signal transduction by p53 class mediator • negative regulation of apoptotic process • negative regulation of mature B cell apoptotic process • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • protein homotrimerization • negative regulation of cell cycle arrest • positive regulation of lipopolysaccharide-mediated signaling pathway • cell aging • cell surface receptor signaling pathway • negative regulation of DNA damage response, signal transduction by p53 class mediator • regulation of cell proliferation • positive regulation of arachidonic acid secretion • positive regulation of B cell proliferation • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of prostaglandin secretion involved in immune response • prostaglandin biosynthetic process • innate immune response • negative regulation of myeloid cell apoptotic process • inflammatory response • cell proliferation • positive regulation of phosphorylation • positive regulation of myeloid leukocyte cytokine production involved in immune response • leukocyte migration • regulation of macrophage activation • positive regulation of protein kinase A signaling • positive chemotaxis • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4282


17319

Ensembl


n/a


ENSMUSG00000033307

UniProt


P14174


P34884

RefSeq (mRNA)


NM_002415


NM_010798

RefSeq (protein)


NP_002406 NP_002406.1


NP_034928.1 NP_034928

Location (UCSC)

Chr 22: 23.89 – 23.9 Mb

Chr 10: 75.86 – 75.86 Mb

PubMed search

Macrophage migration inhibitory factor (MIF)

Identifiers

Symbol

MIF

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

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