Macrophage colony-stimulating factor

CSF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM

Identifiers

CSF1, CSF-1, MCSF, colony stimulating factor 1

External IDs

MGI: 1339753 HomoloGene: 7282 GeneCards: CSF1

Gene ontology
Molecular function	• protein binding • macrophage colony-stimulating factor receptor binding • protein homodimerization activity • growth factor activity • cytokine activity
Cellular component	• integral component of membrane • extracellular region • perinuclear region of cytoplasm • extracellular exosome • CSF1-CSF1R complex • membrane • extracellular space • plasma membrane
Biological process	• positive regulation of microglial cell migration • cell differentiation • hemopoiesis • positive regulation of cellular protein metabolic process • mammary gland fat development • branching involved in mammary gland duct morphogenesis • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • positive regulation of Ras protein signal transduction • positive regulation of macrophage colony-stimulating factor signaling pathway • mammary duct terminal end bud growth • monocyte activation • positive regulation of macrophage derived foam cell differentiation • positive regulation of gene expression • macrophage colony-stimulating factor signaling pathway • positive regulation of odontogenesis of dentin-containing tooth • positive regulation of cell proliferation • regulation of macrophage derived foam cell differentiation • positive regulation of multicellular organism growth • homeostasis of number of cells within a tissue • regulation of ossification • inflammatory response • positive regulation of macrophage chemotaxis • innate immune response • positive regulation of mononuclear cell proliferation • osteoclast proliferation • positive regulation of osteoclast differentiation • positive regulation of cell migration • positive regulation of monocyte differentiation • positive regulation of protein kinase activity • developmental process involved in reproduction • positive regulation of cell-matrix adhesion • positive regulation of macrophage differentiation • cell proliferation • osteoclast differentiation • macrophage differentiation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE CSF1 211839 s at fs.png

PBB GE CSF1 207082 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


1435


12977


ENSG00000184371


ENSMUSG00000014599


P09603


P07141

RefSeq (mRNA)


NM_172212 NM_000757 NM_172210 NM_172211


NM_001113529 NM_001113530 NM_007778

RefSeq (protein)


NP_000748 NP_757349 NP_757350 NP_757351

NP_001107001.1 NP_001107002.1 NP_031804.3 NP_001107001 NP_001107002
NP_031804

Location (UCSC)

Chr 1: 109.91 – 109.93 Mb

Chr 3: 107.74 – 107.76 Mb

PubMed search

1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM

ENSG00000184371

ENSMUSG00000014599

NM_172212
NM_000757
NM_172210
NM_172211

NM_001113529
NM_001113530
NM_007778

NP_000748
NP_757349
NP_757350
NP_757351

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Wikipedia

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