Mabel Irene Lockerby (March 13, 1882 – May 1, 1976) was a Canadian artist. She sometimes gave her birth year as 1887.
The daughter of Alexander Lockerby, a grocer, and Barbara Cox, she was born in Montreal and studied at the Art Association of Montreal with William Brymner and Maurice Cullen. She was a member of the Beaver Hall Group, of the Canadian Group of Painters and of the Contemporary Arts Society of Montreal. Her work was exhibited in the British Empire Exhibition at Wembley Park, Wembley, England in 1924 and 1925, at the National Gallery of Canada, at the 1939 New York World's Fair and at the 400th Anniversary Exhibition in Sao Paulo, Brazil in 1954.
Lockerby died in Montreal at the age of 94 after suffering a stroke a few months earlier.
Her work is included in the collections of the National Gallery of Canada, the Art Gallery of Ontario and the Art Gallery of Hamilton.