MYO7A

MYO7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PVL
Identifiers
Aliases	MYO7A, DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B, myosin VIIA
External IDs	OMIM: 276903 MGI: 104510 HomoloGene: 219 GeneCards: MYO7A
Gene ontology Molecular function • nucleotide binding • spectrin binding • protein homodimerization activity • protein domain specific binding • protein N-terminus binding • actin-dependent ATPase activity • protein complex binding • ADP binding • calmodulin binding • actin filament binding • microfilament motor activity • protein binding • actin binding • motor activity • ATP binding Cellular component • cytosol • photoreceptor inner segment • melanosome • photoreceptor outer segment • stereocilium • photoreceptor connecting cilium • microvillus • lysosomal membrane • cell cortex • apical plasma membrane • myosin VII complex • upper tip-link density • cytoskeleton • myosin complex • synapse • cytoplasm Biological process • sensory perception • inner ear receptor stereocilium organization • pigment granule localization • sensory perception of light stimulus • post-embryonic animal organ morphogenesis • sensory perception of sound • mechanoreceptor differentiation • pigment granule transport • auditory receptor cell stereocilium organization • phagolysosome assembly • auditory receptor cell differentiation • cell projection organization • equilibrioception • inner ear morphogenesis • eye photoreceptor cell development • phagocytosis • inner ear development • inner ear receptor cell differentiation • intracellular protein transport • lysosome organization • visual perception • actin filament-based movement Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4647	17921
Ensembl	ENSG00000137474	ENSMUSG00000030761
UniProt	Q13402	P97479
RefSeq (mRNA)	NM_000260 NM_001127179 NM_001127180	NM_001256081 NM_001256082 NM_001256083 NM_008663
RefSeq (protein)	NP_000251 NP_001120651 NP_001120652	NP_001243010.1 NP_001243012.1 NP_032689.2 NP_001243010 NP_001243011 NP_001243012 NP_032689
Location (UCSC)	Chr 11: 77.13 – 77.22 Mb	Chr 7: 98.05 – 98.12 Mb
PubMed search

3PVL

4647

17921

ENSG00000137474

ENSMUSG00000030761

Q13402

P97479

NM_000260
NM_001127179
NM_001127180

NM_001256081
NM_001256082
NM_001256083
NM_008663

NP_000251
NP_001120651
NP_001120652

NP_001243012
NP_032689

Myosin VIIA is protein that in humans is encoded by the MYO7A gene. Myosin VIIA is a member of the unconventional myosin superfamily of proteins. Myosins are actin binding molecular motors that use the enzymatic conversion of ATP - ADP + inorganic phosphate (Pi) to provide the energy for movement.

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