MYLK2

MYLK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LV6, 3KF9
Identifiers
Aliases	MYLK2, KMLC, MLCK, MLCK2, skMLCK, myosin light chain kinase 2
External IDs	MGI: 2139434 HomoloGene: 13223 GeneCards: MYLK2
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • calmodulin binding • myosin light chain kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • calmodulin-dependent protein kinase activity • ATP binding Cellular component • cytoplasm • sarcomere • nucleus Biological process • regulation of muscle filament sliding • cardiac muscle contraction • phosphorylation • cardiac muscle tissue morphogenesis • skeletal muscle satellite cell differentiation • protein phosphorylation • neuromuscular synaptic transmission • positive regulation of gene expression • skeletal muscle cell differentiation • protein autophosphorylation • peptidyl-threonine phosphorylation • striated muscle contraction • peptidyl-serine phosphorylation • intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85366	228785
Ensembl	ENSG00000101306	ENSMUSG00000027470
UniProt	Q9H1R3	Q8VCR8
RefSeq (mRNA)	NM_033118	NM_001081044
RefSeq (protein)	NP_149109	NP_001074513.2 NP_001074513
Location (UCSC)	Chr 20: 31.82 – 31.83 Mb	Chr 2: 152.91 – 152.92 Mb
PubMed search

2LV6, 3KF9

85366

228785

ENSG00000101306

ENSMUSG00000027470

Q9H1R3

Q8VCR8

NM_033118

NM_001081044

NP_149109

NP_001074513.2
NP_001074513

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.

This gene encodes a myosin light chain kinase, a calcium / calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. The MYLK2 gene expresses skMLCK more prevalently in fast twitch muscle fibers as compared to slow twitch muscle fibers. Calmodulin is composed of two terminal domains (N,C) each containing two E-F hand motifs that bind to Ca2+. Upon saturation of Ca2+, Calmodulin undergoes a conformation change allowing it to bind with a target protein such as skMLCK. An image depicting a similar complex (sdCen/skMLCK2) is shown under myosin light chain kinase. This binding to skMLCK increases the affinity of Ca2+ and ultimately leads to a sustained muscle action.

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Wikipedia